81452-54-2

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C7H8O2S/c1-5-3-4-10-6(5)7(8)9-2/h3-4H,1-2H3

Upstream product

• 16494-40-9 2-iodo-3-methylthiophene 
• 616-38-6 carbonic acid dimethyl ester 
• 62353-77-9 3-iodothiophene-2-carboxylic acid methyl ester 
• 59201-86-4 tris(diethylamino)sulfonium difluorotrimethylsiliconate 
• 126507-27-5 3-methyl-2-thienylmagnesium iodide 
• 67-56-1 methanol 
• 23806-24-8 3-methyl-2-thiophenecarboxylic acid 
• 33944-98-8 (E)-(phenylsulfinyl)but-3-en-2-one 
• 42271-17-0 sodium (2-methoxy-2-oxoethyl)sulfanide 
• 61341-26-2 3-methylthenoyl chloride 
• 5834-16-2 3-methyl-2-thiophenecarboxaldehdye 
• 1184731-51-8 2-(1-methoxybut-2-ynyl)-3-methylthiophene 
• 56-23-5 tetrachloromethane 
• 616-44-4 3-Methylthiophene 

Downstream Products

• 265652-38-8 methyl 4-bromo-3-methylthiophene-2-carboxylate 
• 648412-53-7 methyl 4,5-dibromo-3-methylthiophene-2-carboxylate 
• 854626-34-9 3-methyl-4,5-dichlorothiophene-2-carboxylic acid 
• 59961-15-8 methyl 3-(bromomethyl)thiophene-2-carboxylate 
• 22099-20-3 methyl 3-methyl-5-phenylthiophene-2-carboxylate 
• 1372696-64-4 5-(4-chlorophenyl)-3-methylthiophene-2-carboxylic acid methyl ester 
• 1372696-74-6 methyl 5-(3-formylphenyl)-3-methylthiophene-2-carboxylate 
• 1372696-69-9 methyl 5-(3-cyanophenyl)-3-methylthiophene-2-carboxylate 
• 1372696-94-0 methyl 5-(2-methoxycarbonylphenyl)-3-methylthiophene-2-carboxylate 
• 1101167-54-7 4-5-methyl(thiophen-2-yl)benzonitrile 
• 1353717-30-2 4-(3-methylthiophen-2-yl)benzonitrile 
• 1372696-33-7 methyl 5-(4-cyanophenyl)-3-methylthiophene-2-carboxylate 
• 1372696-88-2 methyl 5-(2-cyanophenyl)-3-methylthiophene-2-carboxylate 
• 1372696-78-0 methyl 3-methyl-5-(3-nitrophenyl)-thiophene-2-carboxylate 

Relevant academic research and scientific papers

MALT1 MODULATORS AND USES THEREOF

Provided herein are compounds, compositions, and methods useful for modulating MALT1 and for treating related diseases, disorders, and conditions.

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with methyl tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes.

7-(MORPHOLINYL)-2-(N-PIPERAZINYL) METHYL THIENO [2, 3-C] PYRIDINE DERIVATIVES AS ANTICANCER DRUGS

The present invention relates to novel series of substituted 7-(morpholinyl)-2-(N-piperazinyl)-methyl thieno [2, 3-c] pyridines of the following structure of formula I. Where in R1, R2, R3 and R4 are defined.

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with exc

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

OXAZOLE AND ISOXAZOLE CRAC MODULATORS

The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).

PYRIDAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF

Pyridazinone compounds of Formula (I) including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF

Pyridone and pyrazinone compounds of Formula (I) including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal nitric oxide synthase

Two isomeric N-(memoxycarbonylmienylmemyl)mioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethyl- thioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).

Gold-catalyzed oxidative cleavage of aryl-substituted alkynyl ethers using molecular oxygen. Simultaneous degradation of C-H and single and triple carbon-carbon bonds under ambient conditions

We report the gold-catalyzed oxidative cleavage of aryl-substituted alkynyl ethers using molecular oxygen under ambient conditions; the transformation involves a remarkable cleavage of C-H, C-C and CC bonds simultaneously.