6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol

Base Information

Chemical Name:6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol
CAS No.:197862-48-9
Molecular Formula:C₁₆H₂₀O₃S₂
Molecular Weight:324.465
Hs Code.:

6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ<sup>6</sup>-thiophen-2-yl)-hex-1-en-3-ol

Synonyms:6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol

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Chemical Property of 6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol

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Technology Process of 6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol

There total 4 articles about 6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1826-67-1
vinyl magnesium bromide

: 197862-46-7
4-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

: 197862-48-9
6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol

Guidance literature:: With pyridinium chlorochromate; In tetrahydrofuran; at 0 ℃; for 0.25h;
DOI:10.1002/jccs.199700055

Reference yield:

: 64741-13-5
3-thiophenyl-3-sulfolene

: 197862-48-9
6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) HMPA, BuLi / 1.) THF, hexane, from -105 deg C to -90 deg C, 2.) THF, hexane from -90 deg C to -50 deg C

2: 1.) 9-borabicyclo<3.3.1>nonane, 2.) aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, from 0 deg C to RT, 2.) THF, from 0 deg C to RT

3: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

4: 63 percent / pyridinium chlorochromate / tetrahydrofuran / 0.25 h / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; dihydrogen peroxide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jccs.199700055

Reference yield:

: 197862-42-3
2-But-3-enyl-4-phenylsulfanyl-2,5-dihydro-thiophene 1,1-dioxide

: 197862-48-9
6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 9-borabicyclo<3.3.1>nonane, 2.) aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, from 0 deg C to RT, 2.) THF, from 0 deg C to RT

2: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

3: 63 percent / pyridinium chlorochromate / tetrahydrofuran / 0.25 h / 0 °C

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jccs.199700055