2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine

Base Information

Chemical Name:2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine
CAS No.:628316-75-6
Molecular Formula:C₄₃H₄₄Cl₂N₄O₁₂
Molecular Weight:879.748
Hs Code.:

Synonyms:2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine

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Chemical Property of 2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine

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Technology Process of 2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine

There total 1 articles about 2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 5451-40-1
2,6 dichloropurine

: 197644-83-0
1,2-di-O-acetyl-3-O-(3',4'-di-O-acetyl-2',6'-di-O-benzyl-α-D-glucopyranosyl)-5-O-benzyl-α/β-D-ribofuranoside

: 628316-75-6
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 60 ℃; for 1h;
DOI:10.1021/jm030883f

Reference yield: 67.0%

: 593-51-1
methylamine hydrochloride

: 628316-75-6
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine

: 628316-89-2
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2-chloro-6-methylamino-9-β-D-ribofuranosylpurine

Guidance literature:: With triethylamine; In ethanol; dichloromethane; at 60 ℃; for 4h;
DOI:10.1021/jm030883f

Reference yield:

: 628316-75-6
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2,6-dichloro-9-β-D-ribofuranosylpurine

: 628316-91-6
2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-2-methoxy-6-methylamino-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / Et₃N / CH₂Cl₂; ethanol / 4 h / 60 °C

2: 84 percent / NaOMe; MeOH / 0.5 h / 20 °C

3: 71 percent / methanol / Heating

With methanol; sodium methylate; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm030883f