(2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane

Base Information

Chemical Name:(2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane
CAS No.:749900-34-3
Molecular Formula:C₂₃H₃₈O₃Si
Molecular Weight:390.638
Hs Code.:

Synonyms:(2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane

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Technology Process of (2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane

There total 1 articles about (2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: (1E,4R)-5-hydroxy-2-methyl-4-hydroxymethyl-1-trimethylsilyl-1-decene

: 749900-34-3
(2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ja048493l

Reference yield: 91.0%

: 749900-34-3
(2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane

: 327165-42-4
(1E,4R,5S)-4-hydroxymethyl-5-p-methoxybenzyloxy-2-methyl-1-trimethylsilyl-1-decene

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at 20 ℃; for 32h;
DOI:10.1021/ja048493l

Reference yield:

: 749900-34-3
(2R,4S,5S)-5-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-2-(4-methoxyphenyl)-4-pentyl-1,3-dioxane

: 327165-58-2
(2R,3S)-2-(2-methyl-3-trimethylsilyl-E-prop-2-en-1-yl)-3-(p-methoxybenzyloxy)octanal

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / DIBAL-H / toluene; hexane / 32 h / 20 °C

2: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In hexane; dichloromethane; toluene; 2: Swern oxidation;
DOI:10.1021/ja048493l