2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

Base Information

Chemical Name:2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide
CAS No.:1599475-08-7
Molecular Formula:C₂₂H₁₇F₂N₃OS
Molecular Weight:409.459
Hs Code.:

Synonyms:2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

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Chemical Property of 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

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Technology Process of 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

There total 5 articles about 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 535961-78-5
2-fluoro-6-methylbenzoyl chloride

: 1599475-30-5
C₁₄H₁₂FN₃S

: 1599475-08-7
2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

Guidance literature:: 2-fluoro-6-methylbenzoyl chloride; C₁₄H₁₂FN₃S; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

With water; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1345118-67-3
1-Methyl-3-(2-fluorophenyl)pyrazol-5-yl boronic acid

: 1599475-08-7
2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: hydrogen; palladium on activated charcoal / methanol

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

: 149739-32-2
3-(2-fluorophenyl)-1H-pyrazole

: 1599475-08-7
2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 1 h

1.2: 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C

2.2: -78 - 20 °C

2.3: 0.5 h

3.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.1: hydrogen; palladium on activated charcoal / methanol

5.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;