2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

Base Information

• Chemical Name: 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide
• CAS No.: 1599475-08-7
• Molecular Formula: C₂₂H₁₇F₂N₃OS
• Molecular Weight: 409.459
• Mol file: 1599475-08-7.mol

Synonyms:2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

Chemical Property of 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide

There total 5 articles about 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

2-fluoro-6-methylbenzoyl chloride (535961-78-5) + C14H12FN3S (1599475-30-5) → 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide (1599475-08-7)

Guidance literature:

2-fluoro-6-methylbenzoyl chloride; C₁₄H₁₂FN₃S; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

With water; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

1-Methyl-3-(2-fluorophenyl)pyrazol-5-yl boronic acid (1345118-67-3) → 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide (1599475-08-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: hydrogen; palladium on activated charcoal / methanol

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

3-(2-fluorophenyl)-1H-pyrazole (149739-32-2) → 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide (1599475-08-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 1 h

1.2: 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C

2.2: -78 - 20 °C

2.3: 0.5 h

3.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.1: hydrogen; palladium on activated charcoal / methanol

5.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;

upstream raw materials:

3-(2-fluorophenyl)-1H-pyrazole

3-(2-fluorophenyl)-1-methylpyrazole

1-Methyl-3-(2-fluorophenyl)pyrazol-5-yl boronic acid

C₁₄H₁₀FN₃O₂S