tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate
CAS No.:1454273-81-4
Molecular Formula:C₃₇H₃₈F₇N₅O₆
Molecular Weight:781.727
Hs Code.:

tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

Synonyms:tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

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Chemical Property of tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

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Technology Process of tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

There total 6 articles about tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1454273-80-3
tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-(3-nitrophenyl)ethyl)carbamate

: 1454273-81-4
tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

Guidance literature:: With hydrogen; In methanol; at 20 ℃; for 15h;

Reference yield:

: 30077-08-8
d-α-amino-m-nitrophenylacetic acid

: 1454273-81-4
tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / methanol / Inert atmosphere; Cooling with ice; Reflux

2: triethylamine; sodium hydrogencarbonate / dichloromethane / 20 °C

3: tetrahydrofuran / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

5: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

6: hydrogen / methanol / 15 h / 20 °C

With thionyl chloride; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;

Reference yield:

: 687631-80-7,76604-97-2
methyl 2-amino-2-(3-nitrophenyl)acetate

: 1454273-81-4
tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; sodium hydrogencarbonate / dichloromethane / 20 °C

2: tetrahydrofuran / 20 °C / Cooling with ice

3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4: potassium carbonate; tetrabutylammomium bromide / acetone / 15 h / 70 °C

5: hydrogen / methanol / 15 h / 20 °C

With tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;