2-Chloro-5-ethylaminomethylpyridine

Base Information

• Chemical Name: 2-Chloro-5-ethylaminomethylpyridine
• CAS No.: 120739-77-7
• Molecular Formula: C8H11ClN2
• Molecular Weight: 170.642
• DSSTox Substance ID: DTXSID80456521
• Nikkaji Number: J1.633.875C
• Wikidata: Q72449972
• Mol file: 120739-77-7.mol

Synonyms:2-Chloro-5-(ethylaminomethyl)pyridine;2-Chloro-5-ethylaminoethylpyridine;N-((6-Chloropyridin-3-yl)methyl)ethanamine;N-(6-Chloro-3-pyridylmethyl)-N-ethylamine;

Chemical Property of 2-Chloro-5-ethylaminomethylpyridine

Chemical Property:

• Boiling Point: 254℃
• Flash Point: 108℃
• PSA: 24.92000
• Density: 1.117
• LogP: 2.23540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 170.0610761
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

2-?Chloro-?5-?ethylaminoMethylPyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC1=CN=C(C=C1)Cl
• Uses: 2-?Chloro-?5-?ethylamino Methyl Pyridine is an impurity of Nitenpyram (N490115), a chloronicotinyl insecticide; orally administered flea adulticide. Nitenpyram is used as an ectoparasiticide.

Technology Process of 2-Chloro-5-ethylaminomethylpyridine

There total 5 articles about 2-Chloro-5-ethylaminomethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + ethylamine (75-04-7,85404-22-4) → N-(6-chloro-pyridin-3-yl)methyl-N-ethylamine (120739-77-7)

Guidance literature:

In acetonitrile; at 0 ℃; for 3.5h;

Reference yield: 86.3%

→ N-(6-chloro-pyridin-3-yl)methyl-N-ethylamine (120739-77-7)

Guidance literature:

Reference yield: 50.9%

2-chloro-5-(dichloromethyl)-pyridine (72637-18-4) + ethylamine (75-04-7,85404-22-4) → N-(6-chloro-pyridin-3-yl)methyl-N-ethylamine (120739-77-7)

Guidance literature:

aluminum nickel; In ethanol;

upstream raw materials:

2-chloro-5-(dichloromethyl)-pyridine

ethylamine

2-chloro-5-(Trichloromethyl)-pyridine

2-chloro-5-(chloromethyl)pyridine

Downstream raw materials:

1-[N-(2-chloro-5-pyridylmethyl)-N-n-ethylamino]-1-methylamino-2-nitroethylene

nitenpiram

S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-phenylpropanoic acid methyl ester

S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester