{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester

Base Information

Chemical Name:{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester
CAS No.:177977-05-8
Molecular Formula:C₂₄H₃₃NO₅
Molecular Weight:415.53
Hs Code.:

Synonyms:{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester

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Chemical Property of {(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester

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Technology Process of {(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester

There total 18 articles about {(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177977-02-5
C₃₆H₄₅NO₅S₂

: 177977-05-8
{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 80 percent / N-chlorosuccinimide; aq. AgNO₃ / acetonitrile / 0.33 h / 0 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / 0 °C

2.2: 91.1 percent / hexane; tetrahydrofuran / 1.5 h / 0 °C

3.1: 100 percent / Et₃SiH / 10percent Pd/C / acetone / 1.5 h / 20 °C

4.1: 100 percent / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C

5.1: diphenylphosphoryl azide; Et₃N / dimethylformamide / 0.5 h / 60 °C

6.1: 3.30 g / CuCl / dimethylformamide / 40 h / 20 °C

With triethylsilane; sodium chlorite; sodium dihydrogenphosphate; N-chloro-succinimide; n-butyllithium; 2-methyl-but-2-ene; diphenylphosphoranyl azide; silver nitrate; triethylamine; copper(l) chloride; 10percent Pd/C; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; 6.1: Curtius rearrangement;
DOI:10.1002/1521-3765(20011001)7:19<4107::AID-CHEM4107>3.0.CO;2-K

Reference yield:

: 177977-03-6
(4R,5S)-3-{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl}-4-methyl-5-phenyl-oxazolidin-2-one

: 177977-05-8
{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / 0 °C

1.2: 91.1 percent / hexane; tetrahydrofuran / 1.5 h / 0 °C

2.1: 100 percent / Et₃SiH / 10percent Pd/C / acetone / 1.5 h / 20 °C

3.1: 100 percent / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C

4.1: diphenylphosphoryl azide; Et₃N / dimethylformamide / 0.5 h / 60 °C

5.1: 3.30 g / CuCl / dimethylformamide / 40 h / 20 °C

With triethylsilane; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; diphenylphosphoranyl azide; triethylamine; copper(l) chloride; 10percent Pd/C; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 5.1: Curtius rearrangement;
DOI:10.1002/1521-3765(20011001)7:19<4107::AID-CHEM4107>3.0.CO;2-K

Reference yield:

: 177977-13-8
(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbothioic acid S-ethyl ester

: 177977-05-8
{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃SiH / 10percent Pd/C / acetone / 1.5 h / 20 °C

2: 100 percent / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C

3: diphenylphosphoryl azide; Et₃N / dimethylformamide / 0.5 h / 60 °C

4: 3.30 g / CuCl / dimethylformamide / 40 h / 20 °C

With triethylsilane; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diphenylphosphoranyl azide; triethylamine; copper(l) chloride; 10percent Pd/C; In N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 4: Curtius rearrangement;
DOI:10.1002/1521-3765(20011001)7:19<4107::AID-CHEM4107>3.0.CO;2-K