2-FLUORO-3-HYDROXY-6-PICOLINE

Base Information

• Chemical Name: 2-FLUORO-3-HYDROXY-6-PICOLINE
• CAS No.: 209328-87-0
• Molecular Formula: C₆H₆FNO
• Molecular Weight: 127.118
• Hs Code.: 2933399990
• Mol file: 209328-87-0.mol

Synonyms:2-Fluoro-3-hydroxy-6-methylpyridine;

Chemical Property of 2-FLUORO-3-HYDROXY-6-PICOLINE

Chemical Property:

• Vapor Pressure: 0.00127mmHg at 25°C
• Refractive Index: 1.523
• Boiling Point: 289.4 °C at 760 mmHg
• PKA: 5.26±0.10(Predicted)
• Flash Point: 128.8 °C
• PSA: 33.12000
• Density: 1.252 g/cm³
• LogP: 1.23470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-3-hydroxy-6-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-FLUORO-3-HYDROXY-6-PICOLINE

There total 2 articles about 2-FLUORO-3-HYDROXY-6-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-amino-3-hydroxy-6-methylpyridine (20348-16-7) → 2-fluoro-6-methylpyridin-3-ol (209328-87-0)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; at 0 - 5 ℃; for 5h;

DOI:10.1016/j.bioorg.2019.01.037

Reference yield:

6-methyl-2-nitropyridin-3-ol (15128-90-2) → 2-fluoro-6-methylpyridin-3-ol (209328-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 20 - 25 °C

2: sodium nitrite; tetrafluoroboric acid / 5 h / 0 - 5 °C

With tetrafluoroboric acid; palladium 10% on activated carbon; hydrogen; sodium nitrite; In ethanol;

DOI:10.1016/j.bioorg.2019.01.037

Reference yield:

2-fluoro-6-methylpyridin-3-ol (209328-87-0) + 4-fluorobenzaldehyde (459-57-4) → 4-((2-fluoro-6-methylpyridin-3-yl)oxy)benzaldehyde

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1021/acs.jmedchem.8b01789

upstream raw materials:

2-amino-3-hydroxy-6-methylpyridine

6-methyl-2-nitropyridin-3-ol

Downstream raw materials:

3-Ethoxy-2-fluoro-6-methylpyridine

Refernces

• 1、 -. "3-Pyridyl enantiomers and their use as analgesics". . . Retrieved 2008/06/13.