(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

Base Information

Chemical Name:(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine
CAS No.:486460-07-5
Molecular Formula:C₁₆H₁₉F₃N₂O₂
Molecular Weight:328.334
Hs Code.:

Synonyms:(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

Suppliers and Price of (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

There total 2 articles about (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 157911-56-3
2,4,5-trifluorobenzyl bromide

: 486460-07-5
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

Guidance literature:: (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

2,4,5-trifluorobenzyl bromide; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jm0493156

Reference yield:

: 486460-07-5
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

Guidance literature:

Reference yield:

: 486460-07-5
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

: 486460-23-5
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. HCl / acetonitrile / 72 h / 20 °C

1.2: 2.41 g / triethylamine / CH₂Cl₂ / 16 h / 20 °C

2.1: aq. LiOH / tetrahydrofuran / 20 °C

3.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C

3.2: 0.36 g / diethyl ether / 1 h

4.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication

5.1: 71 percent / HOBT; EDC / dimethylformamide / 16 h / 20 °C

With hydrogenchloride; lithium hydroxide; silver benzoate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0493156