2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide

Base Information

• Chemical Name: 2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide
• CAS No.: 122410-40-6
• Molecular Formula: C₁₇H₁₉NO₃S
• Molecular Weight: 317.409
• Mol file: 122410-40-6.mol

Synonyms:2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide

Chemical Property of 2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide

There total 3 articles about 2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Thioacetic acid S-[2-(3,4-dihydroxy-benzylcarbamoyl)-3-phenyl-propyl] ester (122410-25-7) → 2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide (122410-40-6)

Guidance literature:

With sodium hydroxide; In methanol; for 2.5h;

DOI:10.1021/jm00132a005

Reference yield:

3,4-dihydroxybenzylamine hydrobromide (16290-26-9) → 2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide (122410-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) ethyl chloroformate, N(Et)3 / 1) THF, 0 deg C, 30 min, 2) 16 h

2: 84 percent / 1 N NaOH / methanol / 2.5 h

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol;

DOI:10.1021/jm00132a005

Reference yield:

3-acetylthio-2-benzylpropanoic acid (91702-98-6,80969-99-9) → 2-benzyl-3-mercaptopropionic acid 3,4-dihydroxybenzylamide (122410-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) ethyl chloroformate, N(Et)3 / 1) THF, 0 deg C, 30 min, 2) 16 h

2: 84 percent / 1 N NaOH / methanol / 2.5 h

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol;

DOI:10.1021/jm00132a005

upstream raw materials:

Thioacetic acid S-[2-(3,4-dihydroxy-benzylcarbamoyl)-3-phenyl-propyl] ester

3,4-dihydroxybenzylamine hydrobromide

3-acetylthio-2-benzylpropanoic acid

Refernces