3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate

Base Information

Chemical Name:3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate
CAS No.:714273-07-1
Molecular Formula:C₂HF₃O₂*C₁₉H₁₉BrN₄O₂
Molecular Weight:529.313
Hs Code.:

Synonyms:3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate

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Chemical Property of 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate

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Technology Process of 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate

There total 6 articles about 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 714273-84-4
1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

: 6630-33-7
ortho-bromobenzaldehyde

: 76-05-1
trifluoroacetic acid

: 714273-07-1
3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate

Guidance literature:: 1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione; ortho-bromobenzaldehyde; With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile; Inert atmosphere;
DOI:10.1021/jm2009088

Reference yield:

: 714273-83-3
5-(tert-butyl)-1H-imidazole-4-carbaldehyde

: 714273-07-1
3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2.2: Inert atmosphere

With caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm2009088

Reference yield:

: 714273-89-9
5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester

: 714273-07-1
3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2-bromophenyl)methylidene]-2,5-piperazinedione trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 14 h / 165 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: manganese(IV) oxide / acetone / 2 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

5.2: Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm2009088