3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Base Information

• Chemical Name: 3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester
• CAS No.: 620972-27-2
• Molecular Formula: C₁₉H₂₂F₃N₃O₃
• Molecular Weight: 397.397

Synonyms:3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Chemical Property of 3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

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Technology Process of 3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

There total 3 articles about 3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

isobutyric Acid (79-31-2) + α-N-trifluoroacetyl-3-benzyl-L-histidine methyl ester (620972-19-2) → 3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (620972-27-2)

Guidance literature:

With ammonium peroxydisulfate; sulfuric acid; silver nitrate; In water; at 70 ℃;

DOI:10.1081/SCC-120022183

Reference yield:

N-α-trifluoroacetyl-L-histidine methyl ester (1604-44-0) → 3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (620972-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 92 percent / triethylamine / benzene / 1 h / Heating

2.1: CHCl₃ / 20 h / 20 °C

2.2: 75 percent / glacial acetic acid; silver acetate / 20 °C

3.1: 35 percent / AgNO₃; (NH₄)2S₂O₈; H₂SO₄ / H₂O / 70 °C

With ammonium peroxydisulfate; sulfuric acid; silver nitrate; triethylamine; In chloroform; water; benzene;

DOI:10.1081/SCC-120022183

Reference yield:

α-N-trifluoroacetyl-1-trityl-L-histidine methyl ester (620972-18-1) → 3-(3-benzyl-2-isopropyl-3H-imidazol-4-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (620972-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CHCl₃ / 20 h / 20 °C

1.2: 75 percent / glacial acetic acid; silver acetate / 20 °C

2.1: 35 percent / AgNO₃; (NH₄)2S₂O₈; H₂SO₄ / H₂O / 70 °C

With ammonium peroxydisulfate; sulfuric acid; silver nitrate; In chloroform; water;

DOI:10.1081/SCC-120022183

upstream raw materials:

isobutyric Acid

α-N-trifluoroacetyl-3-benzyl-L-histidine methyl ester

N-α-trifluoroacetyl-L-histidine methyl ester

α-N-trifluoroacetyl-1-trityl-L-histidine methyl ester

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