(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

Base Information

Chemical Name:(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol
CAS No.:1307813-44-0
Molecular Formula:C₂₁H₁₃F₃N₂O₄
Molecular Weight:414.34
Hs Code.:

Synonyms:(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

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Chemical Property of (3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

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Technology Process of (3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

There total 19 articles about (3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1307813-43-9
(9b-morpholino-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,9b-dihydro-3aH-chromeno[3,4-d]isoxazol-7-yl)methanol

: 1307813-44-0
(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

Guidance literature:: With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 - 80 ℃; for 1h;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307813-44-0
(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

Guidance literature:: Multi-step reaction with 10 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 20 °C

3: Dess-Martin periodane / dichloromethane / 3.7 h / 0 - 20 °C / Inert atmosphere

4: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 - 80 °C

5: N-chloro-succinimide / N,N-dimethyl-formamide / 0.87 h / 20 °C

6: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

7: trifluoroacetic acid / 1 h / 20 °C

8: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

9: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

10: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 20 - 80 °C

With methanol; sodium tetrahydroborate; sodium periodate; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 76240-27-2
7-hydroxy-2,3-dihydro-4H-chromen-4-one

: 1307813-44-0
(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methanol

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine / 2.58 h / 0 - 20 °C

2: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

4: (R)-10-camphorsulfonic acid / acetone / 20 °C

5: titanium tetrachloride / toluene / 0 - 20 °C

6: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

7: trifluoroacetic acid / 1 h / 20 °C

8: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

9: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

10: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 20 - 80 °C

With methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R)-10-camphorsulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; 1,2-dichloro-ethane; acetone; toluene;