(3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one

Base Information

Chemical Name:(3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one
CAS No.:232280-12-5
Molecular Formula:C₂₉H₄₈N₂O₅Si
Molecular Weight:532.796
Hs Code.:

Synonyms:(3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one

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Chemical Property of (3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one

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Technology Process of (3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one

There total 11 articles about (3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-5-(4-Methoxy-benzyloxy)-2-((S)-3-methyl-2-methylene-4-triisopropylsilanyloxy-butoxy)-pentanoic acid

: 232280-12-5
(3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NEt₃ / diethyl ether / Ambient temperature

2: diethyl ether / Ambient temperature

With triethylamine; In diethyl ether;

Reference yield:

: 232280-19-2
(2R,3R)-1,2-O-isopropylidene-6-[(4-methoxybenzyl)oxy]-3-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexane-1,2-diol

: 232280-12-5
(3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: PPTS / ethane-1,2-diol; tetrahydrofuran; CH₂Cl₂ / Heating

2: NaIO₄, H₂O / tetrahydrofuran

3: PDC / dimethylformamide / Ambient temperature

4: NEt₃ / diethyl ether / Ambient temperature

5: diethyl ether / Ambient temperature

With sodium periodate; dipyridinium dichromate; water; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 232280-12-5
(3R)-1-diazo-6-[(4-methoxybenzyl)oxy]-2-{(3S)-3-methyl-2-methylene-4-[(triisopropylsilyl)oxy]butoxy}hexan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: 99 percent / imidazole / dimethylformamide / Ambient temperature

2: 98 percent / CeCl₃ / tetrahydrofuran / -70 - 20 °C

3: 97 percent / pyrrolidone hydrotribromide, pyridine / tetrahydrofuran / -10 - 20 °C

4: 90 percent / NaH / tetrahydrofuran

5: PPTS / ethane-1,2-diol; tetrahydrofuran; CH₂Cl₂ / Heating

6: NaIO₄, H₂O / tetrahydrofuran

7: PDC / dimethylformamide / Ambient temperature

8: NEt₃ / diethyl ether / Ambient temperature

9: diethyl ether / Ambient temperature

With pyridine; 1H-imidazole; sodium periodate; dipyridinium dichromate; cerium(III) chloride; pyrrolidone hydrotribromide; water; pyridinium p-toluenesulfonate; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;