2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid

Base Information

Chemical Name:2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid
CAS No.:1152535-11-9
Molecular Formula:C₁₂H₁₁ClN₂O₃
Molecular Weight:266.684
Hs Code.:

Synonyms:2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid

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Chemical Property of 2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid

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Technology Process of 2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid

There total 4 articles about 2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1498335-00-4
2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl) acetonitrile

: 1152535-11-9
2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid

Guidance literature:: With sulfuric acid; for 3h; Reflux;
DOI:10.1248/cpb.c13-00314

Reference yield:

: C₁₄H₁₉ClN₃O⁽¹⁺⁾*I^(1-)

: 1152535-11-9
2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; water / 20 °C

2: sulfuric acid / 3 h / Reflux

With sulfuric acid; In methanol; water;
DOI:10.1248/cpb.c13-00314

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1152535-11-9
2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium acetate; acetic acid / 24 h / 20 °C

2.1: 0.5 h / 20 °C

2.2: 70 - 90 °C

2.3: 12 h / 70 - 75 °C

3.1: acetone / 5 - 20 °C

4.1: methanol; water / 20 °C

5.1: sulfuric acid / 3 h / Reflux

With sulfuric acid; sodium acetate; acetic acid; In methanol; water; acetone; 2.1: |Mannich Aminomethylation / 2.2: |Mannich Aminomethylation / 2.3: |Mannich Aminomethylation;
DOI:10.1248/cpb.c13-00314