Tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

Base Information

Chemical Name:Tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate
CAS No.:183673-68-9
Molecular Formula:C22H35N3O8
Molecular Weight:469.535
Hs Code.:
DSSTox Substance ID:DTXSID10394705
Nikkaji Number:J775.702F
Wikidata:Q82194261
Mol file:183673-68-9.mol

Synonyms:183673-68-9;tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate;1,3,8-Tri(Boc)-1,3,8-triazaspiro[4.5]decane-2,4-dione;tritert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate;1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN;MFCD03425516;AC1MTQJD;DTXSID10394705;1-t-Boc-piperidine-4-spiro-5'-[1',3'-bis-t-boc]hydantoin;SY040233;CS-0036916;FT-0663555;W12460;1,1',3'-Tris(tert-butyloxycarbonyl)spiro[piperidine-4,5'-hydantoin];Tri-t-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate;2,4-dioxo-1,3,8-triaza-spiro[4,5]decane-1,3,8-tricarboxylic acid tri-tert butyl ester;1-t-Boc-piperidine-4-spiro-5 inverted exclamation mark -[1 inverted exclamation mark ,3 inverted exclamation mark -bis-t-boc]hydantoin

Suppliers and Price of Tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-t-Boc-piperidine-4-spiro-5’-[1’,3’-bis-t-boc]hydantoin
500mg
$ 120.00

Crysdot
Tri-tert-butyl2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate 97%
5g
$ 559.00

Chemenu
Tri-tert-butyl2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate 97%
5g
$ 528.00

Biosynth Carbosynth
1-t-Boc-piperidine-4-spiro-5'-[1',3'-bis-t-boc]-hydantoin
2 g
$ 660.70

Biosynth Carbosynth
1-t-Boc-piperidine-4-spiro-5'-[1',3'-bis-t-boc]-hydantoin
500 mg
$ 200.00

Biosynth Carbosynth
1-t-Boc-piperidine-4-spiro-5'-[1',3'-bis-t-boc]-hydantoin
250 mg
$ 112.50

Biosynth Carbosynth
1-t-Boc-piperidine-4-spiro-5'-[1',3'-bis-t-boc]-hydantoin
1 g
$ 363.40

Biosynth Carbosynth
1-t-Boc-piperidine-4-spiro-5'-[1',3'-bis-t-boc]-hydantoin
5 g
$ 1201.20

American Custom Chemicals Corporation
1-TERT-BOC-PIPERIDINE-4-SPIRO-5'-(1',3'-BIS-TERT-BOC)-HYDANTOIN 95.00%
5G
$ 1767.15

American Custom Chemicals Corporation
1-TERT-BOC-PIPERIDINE-4-SPIRO-5'-(1',3'-BIS-TERT-BOC)-HYDANTOIN 95.00%
1G
$ 943.95

Total 7 raw suppliers

Chemical Property of Tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

Chemical Property:

Melting Point:242-244°C
PSA：122.76000
LogP:3.70420
Solubility.:Dichloromethane
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:469.24241508
Heavy Atom Count:33
Complexity:839

Purity/Quality:

97% ^*data from raw suppliers

1-t-Boc-piperidine-4-spiro-5’-[1’,3’-bis-t-boc]hydantoin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(C(=O)N2C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Uses A cyclic a,a-disubstituted amino acid for preparation of water-soluble highly helical peptides A cyclic α,α-disubstituted amino acid for preparation of water-soluble highly helical peptides.

Technology Process of Tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

There total 7 articles about Tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 183673-70-3
tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate

: 183673-68-9
1-tert-butyloxycarbonylpiperidine-4-spiro-5'-(1',3'-bis(tertbutyloxy-carbonyl))hydantoin

Guidance literature:: With dmap; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 13625-39-3
1,3,8-triaza-spiro[4.5]decan-2,4-dione

: 183673-68-9
1-tert-butyloxycarbonylpiperidine-4-spiro-5'-(1',3'-bis(tertbutyloxy-carbonyl))hydantoin

Guidance literature:: With dmap; triethylamine; In 1,2-dimethoxyethane; for 21h; Ambient temperature;
DOI:10.1021/jo961594k

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 183673-68-9
1-tert-butyloxycarbonylpiperidine-4-spiro-5'-(1',3'-bis(tertbutyloxy-carbonyl))hydantoin

Guidance literature:: Multi-step reaction with 2 steps

2: DMAP / tetrahydrofuran

With dmap; In tetrahydrofuran;
DOI:10.1021/jo961594k