2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester
CAS No.:1034191-61-1
Molecular Formula:C₂₃H₃₇NO₅
Molecular Weight:407.55
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

Synonyms:2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

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Technology Process of 2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

There total 4 articles about 2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 380306-30-9
1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

: 1034191-61-1
2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 1h;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y

Reference yield:

: 134098-64-9
2‐{3‐[(O‐tert‐butyldimethylsilyl)hydroxy]‐1,1‐dimethylpropyl}‐3,5‐dimethylphenol

: 1034191-61-1
2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / 4-dimethylaminopyridine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

2: glac. HOAc / tetrahydrofuran; H₂O / 1 h / 20 °C

With dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1034191-61-1
2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / 4-dimethylaminopyridine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

2: glac. HOAc / tetrahydrofuran; H₂O / 1 h / 20 °C

With dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y