Fmoc-N-(tert-butyloxycarbonylmethyl)glycine

Base Information

Chemical Name:Fmoc-N-(tert-butyloxycarbonylmethyl)glycine
CAS No.:141743-16-0
Molecular Formula:C23H25 N O6
Molecular Weight:411.455
Hs Code.:29225090
DSSTox Substance ID:DTXSID20441931
Nikkaji Number:J817.519E
Wikidata:Q82258937
Mol file:141743-16-0.mol

Synonyms:141743-16-0;Fmoc-N-(tert-butyloxycarbonylmethyl)glycine;Fmoc-N-(tert-butyloxycarbonylmethyl)-glycine;2-[9H-fluoren-9-ylmethoxycarbonyl-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]acetic acid;2-{[2-(tert-butoxy)-2-oxoethyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}acetic acid;Fmoc-nAsp(OtBu)-OH;SCHEMBL16060098;DTXSID20441931;MFCD05663767;AKOS015911467;Fmoc-N-(t-butyoxycarbonylmethyl)-Gly-OH;AS-74532;Glycine, N-(carboxymethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester;CS-0154832;S11659;EN300-1556640;J-007545;N-(9-Fluorenylmethyloxycarbonyl)-N-(t-butyloxycarbonylmethyl)-glycine;N-(9H-Fluoren-9-ylmethoxycarbonyl)-N-(2-tert-butoxy-2-oxoethyl)glycine;Glycine,N-(carboxymethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,1-(1,1-dimethylethyl)ester

Suppliers and Price of Fmoc-N-(tert-butyloxycarbonylmethyl)glycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fmoc-n-(tert-butyloxycarbonylmethyl)-glycine
100mg
$ 115.00

Iris Biotech GmbH
Fmoc-N-(t-butyoxycarbonylmethyl)-Gly-OH
1 g
$ 170.10

Crysdot
Fmoc-N-(tert-butyloxycarbonylmethyl)glycine 95+%
5g
$ 847.00

Chemenu
Fmoc-N-(tert-butyloxycarbonylmethyl)glycine 95%
5g
$ 799.00

American Custom Chemicals Corporation
FMOC-N-(TERT-BUTYLOXYCARBONYLMETHYL)-GLYCINE 95.00%
250MG
$ 620.00

American Custom Chemicals Corporation
FMOC-N-(TERT-BUTYLOXYCARBONYLMETHYL)-GLYCINE 95.00%
5MG
$ 505.84

Ambeed
Fmoc-N-(tert-butyloxycarbonylmethyl)glycine 95%
1g
$ 138.00

Ambeed
Fmoc-N-(tert-butyloxycarbonylmethyl)glycine 95%
100mg
$ 44.00

AK Scientific
Fmoc-N-(tert-butyloxycarbonylmethyl)-glycine
1g
$ 225.00

Activate Scientific
Fmoc-N-(tert-butyloxycarbonylmethyl)-glycine 95+%
5 g
$ 1116.00

Total 8 raw suppliers

Chemical Property of Fmoc-N-(tert-butyloxycarbonylmethyl)glycine

Chemical Property:

Boiling Point:581.9±43.0 °C(Predicted)
PKA:3.71±0.10(Predicted)
PSA：93.14000
Density:1.258±0.06 g/cm3(Predicted)
LogP:3.66380
Storage Temp.:Store at?0-5°C
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:411.16818752
Heavy Atom Count:30
Complexity:620

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-n-(tert-butyloxycarbonylmethyl)-glycine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CN(CC(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Uses Fmoc-n-(tert-butyloxycarbonylmethyl)-glycine is an intermediate used in the preparation of protected aminoalkyl- and carboxyalkylamino acids

Technology Process of Fmoc-N-(tert-butyloxycarbonylmethyl)glycine

There total 7 articles about Fmoc-N-(tert-butyloxycarbonylmethyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 90303-57-4
N-(ethoxycarbonylmethyl)glycine tert-butyl ester

: 141743-16-0
N-(carboxymethyl)-N-Fmoc-glycine tert-butyl ester

Guidance literature:: N-(ethoxycarbonylmethyl)glycine tert-butyl ester; With lithium hydroxide; In 1,4-dioxane; water; at 5 ℃;

(fluorenylmethoxy)carbonyl chloride; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 6h; Further stages.;
DOI:10.1021/jo011041w

Reference yield: 70.9%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 141743-20-6
(tert-Butoxycarbonylmethyl-amino)-acetic acid

: 141743-16-0
N-(carboxymethyl)-N-Fmoc-glycine tert-butyl ester

Guidance literature:: With triethylamine; In acetonitrile; for 4h; Ambient temperature;
DOI:10.1021/jo961580e

Reference yield:

: 6456-74-2
Glycine tert-butyl ester

: 141743-16-0
N-(carboxymethyl)-N-Fmoc-glycine tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, MgSO₄, 2.) NaBH₄ / 1.) MeOH, room temperature, 1.5 h, 2.) MeOH, -5 deg C (1.5 h), 0 deg C (1 h)

2: 100 percent / diisopropylethylamine / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h

3: 55.4 percent / H₂ / Pd/C / methanol / 4 h / 3102.9 Torr

4: 70.9 percent / aq. Et₃N / acetonitrile / 4 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; magnesium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo961580e