Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

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Chemical Name:Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester
CAS No.:197303-70-1
Molecular Formula:C₆₅H₁₀₁ClN₃O₁₈P
Molecular Weight:1278.95
Hs Code.:

Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

Synonyms:Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

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Chemical Property of Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

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Technology Process of Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

There total 8 articles about Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 83200-46-8
2',3',N⁴-trilevulinyl-1-β-D-arabinofuranosylcytosine

: Hexadecanoic acid (R)-2-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-1-hexadecanoyloxymethyl-ethyl ester; compound with triethyl-amine

: 197303-70-1
Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: With pyridine; 1-methyl-1H-imidazole; 2-mesitylenesulphonyl chloride; for 0.333333h;
DOI:10.1016/S0009-3084(97)00056-X

Reference yield:

: 197303-62-1
4-Oxo-pentanoic acid (2R,3R,4S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-4-(4-oxo-pentanoyloxy)-tetrahydro-furan-3-yl ester

: 197303-70-1
Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / aq. AcOH / 3 h / Ambient temperature

2: 86 percent / 2-mesitylenesulfonyl chloride, 1-methylimidazole / pyridine / 0.33 h

With 1-methyl-1H-imidazole; 2-mesitylenesulphonyl chloride; acetic acid; In pyridine;
DOI:10.1080/07328319808004734

Reference yield:

: 30334-71-5
1,2-dipalmitoyl-sn-glycerol

: 197303-70-1
Hexadecanoic acid (R)-2-{(2-chloro-phenoxy)-[(2R,3R,4S,5R)-5-[2-oxo-4-(4-oxo-pentanoylamino)-2H-pyrimidin-1-yl]-3,4-bis-(4-oxo-pentanoyloxy)-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / CH₂Cl₂; acetonitrile / 0.33 h / Ambient temperature

2: 86 percent / 2-mesitylenesulfonyl chloride, 1-methylimidazole / pyridine / 0.33 h

With pyridine; 1-methyl-1H-imidazole; 2-mesitylenesulphonyl chloride; In pyridine; dichloromethane; acetonitrile;
DOI:10.1080/07328319808004734