N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide

Base Information

Chemical Name:N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide
CAS No.:1275599-59-1
Molecular Formula:C₂₅H₂₇N₃O₆
Molecular Weight:465.506
Hs Code.:

Synonyms:N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide

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Technology Process of N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide

There total 5 articles about N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1275599-57-9
C₂₆H₂₉N₃O₆

: 1275599-59-1
N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 25 ℃; for 1h;
DOI:10.1016/j.bmcl.2010.12.047

Reference yield:

: 27684-84-0
5-bromo-2-nitrophenol

: 1275599-59-1
N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 1 h / 150 °C / Microwave irradiation

2: acetic acid; zinc / 3.5 h / 25 °C

3: dichloromethane / 3 h / 30 °C

4: 18 h / 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; zinc; In 1,4-dioxane; dichloromethane; 1: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.bmcl.2010.12.047

Reference yield:

: 59557-91-4
4-bromo-2-methoxyaniline

: 1275599-59-1
N-(2-hydroxy-4-(2-morpholino-4-oxo-4H-chromen-8-yl)phenyl)-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; N,N-dimethyl acetamide / 0.25 h / 140 °C / Microwave irradiation

3: triethylamine / dichloromethane / 3 h / 25 °C

4: 18 h / 25 °C

5: boron tribromide / dichloromethane / 1 h / -78 - 25 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; boron tribromide; caesium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.bmcl.2010.12.047