C₃₀H₄₄O₈Si

Base Information

• Chemical Name: C₃₀H₄₄O₈Si
• CAS No.: 1571901-06-8
• Molecular Formula: C₃₀H₄₄O₈Si
• Molecular Weight: 560.76

Synonyms:C₃₀H₄₄O₈Si

Chemical Property of C₃₀H₄₄O₈Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₄₄O₈Si

There total 20 articles about C₃₀H₄₄O₈Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) + (R)-6-((S)-(tert-butyldimethylsilyloxy)((1S,2S)-2-((1R,2R)-2-hydroxy-1-(methoxymethoxy)propyl)cyclopropyl)methyl)-5,6-dihydro-2H-pyran-2-one (1571901-05-7) → C30H44O8Si (1571901-06-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1039/c3ob42367k

Reference yield:

(2R,3R,E)-6-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyloxy)hex-4-en-3-ol (1571900-72-5) → C30H44O8Si (1571901-06-8)

Guidance literature:

Multi-step reaction with 18 steps

1.1: diethylzinc / dichloromethane; hexane / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h

4.2: 0.42 h / 0 °C

5.1: dichloromethane / 6 h / 20 °C

6.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

7.1: titanium(IV) isopropylate / dichloromethane / 0.5 h / Inert atmosphere; Molecular sieve

7.2: Inert atmosphere; Molecular sieve

8.1: 1-methyl-1H-imidazole / toluene / 5 h / 20 °C / Inert atmosphere

9.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / -40 °C / Inert atmosphere

10.1: 1H-imidazole / N,N-dimethyl-formamide / 9 h / 20 °C

11.1: methanol; potassium carbonate / 12 h / 20 °C

12.1: N-tosylimidazole; sodium hydride / tetrahydrofuran; mineral oil / 4 h / 0 - 20 °C

13.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -15 °C

13.2: 2 h / 25 °C

14.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 20 °C

15.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 16 h / Reflux

16.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 16 h / 20 °C

17.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C / pH 7

18.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 20 °C

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 1-methyl-1H-imidazole; titanium(IV) isopropylate; methanol; dmap; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; diethylzinc; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-tosylimidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: |Simmons-Smith Cyclopropanation / 4.1: |Swern Oxidation / 4.2: |Swern Oxidation / 5.1: |Wittig Olefination / 14.1: |Steglich Esterification / 18.1: |Mitsunobu Displacement;

DOI:10.1039/c3ob42367k

Reference yield:

(4R,5R,E)-5-(4-methoxybenzyloxy)hex-2-ene-1,4-diol (1571900-66-7) → C30H44O8Si (1571901-06-8)

Guidance literature:

Multi-step reaction with 19 steps

1.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

2.1: diethylzinc / dichloromethane; hexane / -78 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h

5.2: 0.42 h / 0 °C

6.1: dichloromethane / 6 h / 20 °C

7.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

8.1: titanium(IV) isopropylate / dichloromethane / 0.5 h / Inert atmosphere; Molecular sieve

8.2: Inert atmosphere; Molecular sieve

9.1: 1-methyl-1H-imidazole / toluene / 5 h / 20 °C / Inert atmosphere

10.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / -40 °C / Inert atmosphere

11.1: 1H-imidazole / N,N-dimethyl-formamide / 9 h / 20 °C

12.1: methanol; potassium carbonate / 12 h / 20 °C

13.1: N-tosylimidazole; sodium hydride / tetrahydrofuran; mineral oil / 4 h / 0 - 20 °C

14.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -15 °C

14.2: 2 h / 25 °C

15.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 20 °C

16.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 16 h / Reflux

17.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 16 h / 20 °C

18.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C / pH 7

19.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 20 °C

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 1-methyl-1H-imidazole; titanium(IV) isopropylate; methanol; dmap; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; diethylzinc; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-tosylimidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: |Simmons-Smith Cyclopropanation / 5.1: |Swern Oxidation / 5.2: |Swern Oxidation / 6.1: |Wittig Olefination / 15.1: |Steglich Esterification / 19.1: |Mitsunobu Displacement;

DOI:10.1039/c3ob42367k

upstream raw materials:

(2R,3R,E)-6-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyloxy)hex-4-en-3-ol

(4R,5R,E)-5-(4-methoxybenzyloxy)hex-2-ene-1,4-diol

(R)-(+)-1-(2-furyl)ethanol

tert-butyl(((1S,2S)-2-((1R,2R)-2-(4-methoxybenzyloxy)-1(methoxymethoxy)propyl)cyclopropyl)methoxy)dimethylsilane

Downstream raw materials:

(E)-((1R,2R)-1-((1S,2S)-2-((S)-(tert-butyldimethylsilyloxy)((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)cyclopropyl)-1-hydroxypropan-2-yl) 3-(4-methoxyphenyl)acrylate

(E)-((1R,2R)-1-hydroxy-1-((1S,2S)-2-((S)-hydroxy((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)cyclopropyl)propan-2-yl) 3-(4-methoxyphenyl)acrylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1571901-06-8 C₃₀H₄₄O₈Si

Send

Send

Metric Ton KG G Pound L ML

Send

Send