trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

Base Information

• Chemical Name: trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester
• CAS No.: 400898-93-3
• Molecular Formula: C₁₅H₂₈N₂O₄
• Molecular Weight: 300.398
• Mol file: 400898-93-3.mol

Synonyms:trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

Chemical Property of trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

There total 2 articles about trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

trans-[4-(methoxymethylcarbamoyl)cyclohexyl]carbamic acid tert-butyl ester (400898-92-2) + methyl iodide (74-88-4) → trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester (400898-93-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm300256z

Reference yield:

→ trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester (400898-93-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

In N,N-dimethyl-formamide; for 3.5h; Cooling with ice;

Reference yield: 100.0%

trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester (400898-93-3) → trans-(4-formylcyclohexyl)methylcarbamic acid tert-butyl ester (400898-94-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -50 - 15 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/jm300256z

upstream raw materials:

trans-[4-(methoxymethylcarbamoyl)cyclohexyl]carbamic acid tert-butyl ester

methyl iodide

Downstream raw materials:

trans-(4-formylcyclohexyl)methylcarbamic acid tert-butyl ester

trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester