trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

Base Information

Chemical Name:trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester
CAS No.:400898-95-5
Molecular Formula:C₁₄H₂₃Br₂NO₂
Molecular Weight:397.15
Hs Code.:

Synonyms:trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

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Chemical Property of trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

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Technology Process of trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

There total 3 articles about trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 400898-94-4
trans-(4-formylcyclohexyl)methylcarbamic acid tert-butyl ester

: 558-13-4
carbon tetrabromide

: 400898-95-5
trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: carbon tetrabromide; With triethylamine; triphenylphosphine; In dichloromethane; for 0.833333h; Inert atmosphere; Reflux;

trans-(4-formylcyclohexyl)methylcarbamic acid tert-butyl ester; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm300256z

Reference yield:

: 400898-92-2
trans-[4-(methoxymethylcarbamoyl)cyclohexyl]carbamic acid tert-butyl ester

: 400898-95-5
trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / -50 - 15 °C / Inert atmosphere

3.1: triethylamine; triphenylphosphine / dichloromethane / 0.83 h / Inert atmosphere; Reflux

3.2: 16 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300256z

Reference yield:

: 400898-93-3
trans-N-[4-(N-methoxy-N-methylcarbamoyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

: 400898-95-5
trans-[4-(2,2-dibromovinyl)cyclohexyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / -50 - 15 °C / Inert atmosphere

2.1: triethylamine; triphenylphosphine / dichloromethane / 0.83 h / Inert atmosphere; Reflux

2.2: 16 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300256z