N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

Base Information

Chemical Name:N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide
CAS No.:812699-95-9
Molecular Formula:C₂₄H₁₇ClF₃N₅O
Molecular Weight:483.88
Hs Code.:

Synonyms:N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

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Chemical Property of N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

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Technology Process of N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

There total 7 articles about N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 641615-40-9
N*3*-[4-(6-chloropyridin-3-yl)-pyrimidin-2-yl]-4-methylbenzene-1,3-diamine

: 454-92-2
3-(trifluoromethyl)benzoic acid

: 812699-95-9
N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

: 99-55-8
2-methyl-5-nitroaniline

: 812699-95-9
N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

2: hydrogen / nickel

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; nickel; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 152460-07-6
1-(2-methyl-5-nitrophenyl)guanidine

: 812699-95-9
N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / nickel

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; nickel; In DMF (N,N-dimethyl-formamide);