641615-40-9

Upstream product

• 641615-39-6 2-[4-(6-chloropyridin-3-yl)pyrimidin-2-ylamino]-1-methyl-4-nitrobenzene 
• 170140-83-7 1-(6-chloropyridin-3-yl)-3-(dimethylamino)-2-propen-1-one 
• 581076-64-4 (2-methyl-5-aminophenyl)guanidine 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 149281-42-5 6-chloro-N-methoxy-N-methylpyridine-3-carboxamide 

Downstream Products

• 812699-95-9 N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide 
• 641614-90-6 3-bromo-4-(4-methylpiperazin-1-ylmethyl)-N-{3-[4-(6-chloropyridin-3-yl)pyrimidin-2-ylamino]-4-methylphenyl}benzamide 

Relevant academic research and scientific papers

AMIDE DERIVATIVE

The present invention provides an amide derivative represented by the following general formula (1): wherein R1 represents a saturated cyclic amino group, R2 represents alkyl, halogen or haloalkyl, R3 represents hydrogen or halogen, Het 2 represents pyridyl or pyrimidinyl, and Het 1 represents a group of the formula [6], or a salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.

2-AMINOPYRIMIDINE DERIVATIVES AS RAF KINASE INHIBITORS

This application discloses compounds that inhibit Raf kinase having the formula (I), wherein R1 is a phenyl radical or a heteroaryl radical; and R2 is a phenyl radical; or an N-oxide or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of proliferative diseases, such as cancer.