4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

Base Information

Chemical Name:4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline
CAS No.:1310371-03-9
Molecular Formula:C₄₁H₃₀F₃N₃O₂S
Molecular Weight:685.769
Hs Code.:

Synonyms:4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

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Chemical Property of 4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

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Technology Process of 4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

There total 2 articles about 4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.8%

: 875667-84-8
4-methoxy-N-(4-methoxyphenyl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzenamine

: 1310370-99-0
4-(5-bromothiophen-2-yl)-6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridine

: 1310371-03-9
4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 65 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ic1025679

Reference yield:

: 1310371-07-3
1-[2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl]pyridinium iodide

: 1310371-03-9
4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / N,N-dimethyl-formamide / 14 h / 120 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 14 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Kr?hnke condensation / 2: Suzuki reaction;
DOI:10.1021/ic1025679

Reference yield: 61.2%

: 330680-47-2
trichloro(trimethyl-4,4',4''-tricarboxylate-2,2':6',2''-terpyridine)ruthenium

: 1310371-03-9
4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)-phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

: 7732-18-5
water

: silver nitrate

: (4-methoxy-N-(4-methoxyphenyl)-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline(-1H))(trimethyl-4,4',4''-tricarboxylate-2,2':6',2''-terpyridine)ruthenium(II) nitrate dihydrate

Guidance literature:: With N-ethylmorpholine; In tetrahydrofuran; methanol; water; Ru complex and N-ethylmorpholine added to MeOH-H2O-THF soln. of ligand; refluxed for 16 h; AgNO3 added; refluxed for 1.5 h; cooled; preabsorbed on silica; solvent removed in vac.; purified by column chromy. (silica, CH2Cl2-MeOH 9:1); elem. anal.;
DOI:10.1021/ic1025679