6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate)

Base Information

• Chemical Name: 6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate)
• CAS No.: 80639-61-8
• Molecular Formula: C₁₇H₂₉NO₁₀S₃
• Molecular Weight: 503.616
• Mol file: 80639-61-8.mol

Synonyms:6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate)

Chemical Property of 6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate)

There total 5 articles about 6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide (72358-83-9,63413-83-2) + methanesulfonyl chloride (124-63-0) → 6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate) (80639-61-8)

Guidance literature:

With pyridine; at 0 ℃; for 2h;

DOI:10.1021/jo00257a016

Reference yield:

toluene-4-sulfonamide (70-55-3) → 6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate) (80639-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide / 1 h / Heating

1.2: 68 percent / dimethylformamide / 4 h / Heating

2.1: Et₃N

With potassium carbonate; triethylamine; In N,N-dimethyl-formamide; 1.1: dechlorination / 1.2: Alkylation / 2.1: Substitution;

DOI:10.1021/jo9912754

Reference yield:

toluene-4-sulfonamide (70-55-3) → 6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate) (80639-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / K₂CO₃ / dimethylformamide / 96 h / Heating

2: 96 percent / pyridine / 2 h / 0 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jo00257a016

upstream raw materials:

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide

methanesulfonyl chloride

toluene-4-sulfonamide

4-Methyl-N,N-bis-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethyl}-benzenesulfonamide

Downstream raw materials:

4-Dodecyl-10-(4'-methylbenzenesulfonyl)-4,10-diaza-1,7-dioxacyclododecane

4-Octyl-10-(4'-methylbenzenesulfonyl)-4,10-diaza-1,7-dioxacyclododecane

4-Octadecyl-10-(4'-methylbenzenesulfonyl)-4,10-diaza-1,7-dioxacyclododecane

10-benzyl-4-<(4-methylphenyl)sulfonyl>-1,7-dioxa-4,10-diazacyclododecane