2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Base Information

Chemical Name:2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide
CAS No.:1366132-02-6
Molecular Formula:C₁₇H₂₀BF₂N₃O₄S
Molecular Weight:411.237
Hs Code.:

Synonyms:2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

There total 3 articles about 2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869008-40-2
2-amino-5-bromo-N-(2,4-difluorophenyl)pyridine-3-sulphonamide

: 73183-34-3
bis(pinacol)diborane

: 1366132-02-6
2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 100 ℃; for 18h;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1366132-02-6
2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: chlorosulfonic acid / 3 h / Reflux

2: pyridine / 1,4-dioxane / 0 - 50 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 18 h / 100 °C

With pyridine; chlorosulfonic acid; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 3: Suzuki Coupling;

Reference yield:

: 868963-98-8
2-amino-5-bromopyridine-3-sulphonyl chloride

: 1366132-02-6
2-amino-5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1,4-dioxane / 0 - 50 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 18 h / 100 °C

With pyridine; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 2: Suzuki Coupling;