(R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Base Information

• Chemical Name: (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid
• CAS No.: 1418713-83-3
• Molecular Formula: C₃₀H₃₀F₂N₂O₄
• Molecular Weight: 520.576

Synonyms:(R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Chemical Property of (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Chemical Property:

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Technology Process of (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

There total 16 articles about (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate (1418718-56-5) → (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid (1418713-83-3) + (S)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid (1418713-87-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 70 ℃; under 760.051 Torr;

Reference yield:

(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol (1418718-44-1) → (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid (1418713-83-3) + (S)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid (1418713-87-7)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

2: zinc(II) iodide / dichloromethane / 0.67 h / 760.05 Torr / Cooling with ice

3: sulfuric acid / 0 - 85 °C / 760.05 Torr

4: perchloric acid / 0.67 h / 20 °C / 760.05 Torr

5: lithium hydroxide / tetrahydrofuran; methanol; water / 70 °C / 760.05 Torr

With perchloric acid; sulfuric acid; pyridinium chlorochromate; zinc(II) iodide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (1418718-47-4) → (R)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid (1418713-83-3) + (S)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid (1418713-87-7)

Guidance literature:

Multi-step reaction with 4 steps

1: zinc(II) iodide / dichloromethane / 0.67 h / 760.05 Torr / Cooling with ice

2: sulfuric acid / 0 - 85 °C / 760.05 Torr

3: perchloric acid / 0.67 h / 20 °C / 760.05 Torr

4: lithium hydroxide / tetrahydrofuran; methanol; water / 70 °C / 760.05 Torr

With perchloric acid; sulfuric acid; zinc(II) iodide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

methyl 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

C₂₉H₂₉F₂N₃O₂Si

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