methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate
CAS No.:1418718-56-5
Molecular Formula:C₃₁H₃₂F₂N₂O₄
Molecular Weight:534.603
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

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Chemical Property of methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

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Technology Process of methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

There total 15 articles about methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 1418718-50-9
methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

: 1418718-56-5
methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: With perchloric acid; at 20 ℃; for 0.666667h; under 760.051 Torr;

Reference yield:

: 1418718-44-1
(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1418718-56-5
methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

2: zinc(II) iodide / dichloromethane / 0.67 h / 760.05 Torr / Cooling with ice

3: sulfuric acid / 0 - 85 °C / 760.05 Torr

4: perchloric acid / 0.67 h / 20 °C / 760.05 Torr

With perchloric acid; sulfuric acid; pyridinium chlorochromate; zinc(II) iodide; In dichloromethane;

Reference yield:

: 1418718-41-8
methyl 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

: 1418718-56-5
methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / 760.05 Torr / Cooling with ice

2: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

3: zinc(II) iodide / dichloromethane / 0.67 h / 760.05 Torr / Cooling with ice

4: sulfuric acid / 0 - 85 °C / 760.05 Torr

5: perchloric acid / 0.67 h / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; perchloric acid; sulfuric acid; pyridinium chlorochromate; zinc(II) iodide; In tetrahydrofuran; dichloromethane;