4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Base Information

Chemical Name:4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde
CAS No.:1418718-47-4
Molecular Formula:C₂₅H₂₀F₂N₂O₂
Molecular Weight:418.443
Hs Code.:

Synonyms:4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

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Chemical Property of 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

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Technology Process of 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

There total 12 articles about 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418718-44-1
(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1418718-47-4
4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 1.5h; under 760.051 Torr;

Reference yield:

: 1418718-41-8
methyl 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

: 1418718-47-4
4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / 760.05 Torr / Cooling with ice

2: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 493-08-3
chromane

: 1418718-47-4
4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 11 steps

1.1: iodine; silver nitrate / methanol / 1 h / 760.05 Torr

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / 760.05 Torr

2.2: 0.17 h / 20 °C / 760.05 Torr

3.1: piperidine; acetic acid / benzene / 760.05 Torr / Reflux

4.1: 4-methyl-morpholine / isopropyl alcohol / 90 °C / 760.05 Torr

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C / 760.05 Torr

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 0.08 h / 0 °C / 760.05 Torr

7.1: pyridinium chlorochromate / dichloromethane / 20 °C / 760.05 Torr

8.1: caesium carbonate / methanol; hexane / 60 °C / 760.05 Torr

9.1: caesium carbonate / N,N-dimethyl-formamide / 1.25 h / 80 °C / 760.05 Torr

10.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / 760.05 Torr / Cooling with ice

11.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

With piperidine; 4-methyl-morpholine; lithium aluminium tetrahydride; n-butyllithium; iodine; caesium carbonate; silver nitrate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; benzene;