(15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one

Base Information

Chemical Name:(15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one
CAS No.:1424348-38-8
Molecular Formula:C₃₀H₃₅NO₃
Molecular Weight:457.613
Hs Code.:

Synonyms:(15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one

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Chemical Property of (15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one

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Technology Process of (15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one

There total 3 articles about (15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: C₂₆H₂₇ClO₃

: 1424348-38-8
(15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 534572-70-8
(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

: 1424348-38-8
(15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent / acetone / 1.25 h / 0 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1.5 h / 20 °C / Inert atmosphere; Cooling

3: dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

With Jones reagent; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; acetone; toluene;

Reference yield:

: (15α)-3-(benzyloxy)-17-oxoestra-1,3,5(10)-triene-15-carboxylic acid

: 1424348-38-8
(15α)-3-(benzyloxy)-15-(pyrrolidine-1-ylcarbonyl)estra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1.5 h / 20 °C / Inert atmosphere; Cooling

2: dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; toluene;