(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

Base Information

Chemical Name:(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid
CAS No.:534572-70-8
Molecular Formula:C₂₆H₃₀O₄
Molecular Weight:406.522
Hs Code.:

Synonyms:(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

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Chemical Property of (15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

Chemical Property:

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Technology Process of (15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

There total 7 articles about (15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 534572-69-5
3-benzyloxy-15β-cyanoestra-1,3,5(10)-trien-17β-ol

: 534572-70-8
(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

Guidance literature:: With potassium hydroxide; In water; ethylene glycol; at 160 ℃; for 112h;
DOI:10.1021/jm0204340

Reference yield:

: 138743-03-0
(14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one

: 534572-70-8
(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / tetrahydrofuran; H₂O / 2 h / 75 °C

2: NaBH₄ / tetrahydrofuran; methanol / 3.5 h / 20 °C

3: 535 mg / KOH / H₂O; ethane-1,2-diol / 112 h / 160 °C

With potassium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; methanol; water; ethylene glycol;
DOI:10.1021/jm0204340

Reference yield:

: 100-39-0
benzyl bromide

: 534572-70-8
(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / K₂CO₃; diisopropylethylamine / acetone / 72 h / 20 °C

2: 52 percent / pTsOH / acetone; H₂O / 1.5 h / 20 °C

3: 50 percent / tetrahydrofuran; H₂O / 2 h / 75 °C

4: NaBH₄ / tetrahydrofuran; methanol / 3.5 h / 20 °C

5: 535 mg / KOH / H₂O; ethane-1,2-diol / 112 h / 160 °C

With potassium hydroxide; sodium tetrahydroborate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; ethylene glycol; acetone;
DOI:10.1021/jm0204340