6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide

Base Information

• Chemical Name: 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide
• CAS No.: 99082-59-4
• Molecular Formula: C₂₃H₃₆N₂O₄S
• Molecular Weight: 436.616

Synonyms:6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide

Chemical Property of 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide

Chemical Property:

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Technology Process of 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide

There total 1 articles about 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-[bis-(hydroxymethyl)-methyl]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline (98661-43-9) + isothiocyanatocyclohexane (1122-82-3) → 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide (99082-59-4)

Guidance literature:

In benzene; for 1h; Heating;

Reference yield: 77.0%

6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide (99082-59-4) → {(4S,4aS)-1-[(Z)-Cyclohexylimino]-6,7-diethoxy-4,4a,9,10-tetrahydro-3H-2-thia-10a-aza-phenanthren-4-yl}-methanol (124482-27-5)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.5h; Heating;

Reference yield:

6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid cyclohexylamide (99082-59-4) → {(4S,4aS)-1-[(Z)-Cyclohexylimino]-6,7-diethoxy-4,4a,9,10-tetrahydro-3H-2-oxa-10a-aza-phenanthren-4-yl}-methanol (124482-21-9)

Guidance literature:

With potassium hydroxide; methyl iodide; Yield given. Multistep reaction; 1) MeOH, room temp., 3 h, 2) MeOH, 3 h;

upstream raw materials:

1-[bis-(hydroxymethyl)-methyl]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline

isothiocyanatocyclohexane

Downstream raw materials:

{(4S,4aS)-1-[(Z)-Cyclohexylimino]-6,7-diethoxy-4,4a,9,10-tetrahydro-3H-2-oxa-10a-aza-phenanthren-4-yl}-methanol

{(4S,4aS)-1-[(Z)-Cyclohexylimino]-6,7-diethoxy-4,4a,9,10-tetrahydro-3H-2-thia-10a-aza-phenanthren-4-yl}-methanol

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