2,5,6-Trifluoronicotinic aicid nitrile

Base Information

• Chemical Name: 2,5,6-Trifluoronicotinic aicid nitrile
• CAS No.: 870065-73-9
• Molecular Formula: C6H F3 N2
• Molecular Weight: 158.083
• Hs Code.: 2933399090
• Mol file: 870065-73-9.mol

Synonyms:2,5,6-Trifluoronicotinonitrile

Chemical Property of 2,5,6-Trifluoronicotinic aicid nitrile

Chemical Property:

• Vapor Pressure: 0.248mmHg at 25°C
• Boiling Point: 205.619oC at 760 mmHg
• PKA: -11.96±0.20(Predicted)
• Flash Point: 78.156oC
• PSA: 36.68000
• Density: 1.47g/cm3
• LogP: 1.37058
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,5,6-Trifluoro-3-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5,6-Trifluoronicotinic aicid nitrile is a pyridine derivative used in the preparation of JAK2 kinase inhibtors.

Technology Process of 2,5,6-Trifluoronicotinic aicid nitrile

There total 1 articles about 2,5,6-Trifluoronicotinic aicid nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (82671-02-1) → 2,5,6-trifluoropyridine-3-carbonitrile (870065-73-9)

Guidance literature:

With potassium fluoride; In dimethyl sulfoxide; at 20 - 130 ℃; for 0.916667h;

Reference yield: 37.0%

2,5,6-trifluoropyridine-3-carbonitrile (870065-73-9) + 4,4-difluorocyclohexanol (22419-35-8) → 6-((4,4-difluorocyclohexyl)oxy)-2,5-difluoronicotinonitrile

Guidance literature:

4,4-difluorocyclohexanol; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

2,5,6-trifluoropyridine-3-carbonitrile; In tetrahydrofuran; at -70 - 20 ℃; Inert atmosphere;

Reference yield:

2,5,6-trifluoropyridine-3-carbonitrile (870065-73-9) + 4-benzyloxy-butan-1-ol (4541-14-4) → 6-(4-benzyloxy-butoxy)-2,5-difluoro-nicotinonitrile

Guidance literature:

4-benzyloxy-butan-1-ol; With potassium tert-butylate; In tetrahydrofuran; at -70 ℃; for 0.5h;

2,5,6-trifluoropyridine-3-carbonitrile; In tetrahydrofuran; at -72 - -65 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.09.090

upstream raw materials:

2,6-dichloro-5-fluoro-pyridine-3-carbonitrile

Refernces