22419-35-8

Basic information

• Product Name: 4,4-Difluorocyclohexanol
• Synonyms: 4,4-difluorocyclohexanol;1,1-Difluoro-4-hydroxycyclohexane;Cyclohexanol, 4,4-difluoro-
• CAS NO: 22419-35-8
• Molecular Formula: C₆H₁₀F₂O
• Molecular Weight: 136.14
• Mol File: 22419-35-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 60-65°C
• Boiling Point: 160.6 °C at 760 mmHg
• Flash Point: 50.9 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 0.826mmHg at 25°C
• Refractive Index: 1.413
• Storage Temp.: 2-8°C
• PKA: 14.14±0.40(Predicted)
• CAS DataBase Reference: 4,4-Difluorocyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-Difluorocyclohexanol(22419-35-8)
• EPA Substance Registry System: 4,4-Difluorocyclohexanol(22419-35-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 22419-35-8(Hazardous Substances Data)

Usage

Chemical Properties

viscous liquid

Uses

4,?4-?Difluorocyclohexanol is a reagent used in the clearance of adenosine inhibitors of bacterial NAD+-dependent DNA ligase.

InChI:InChI=1/C6H10F2O/c7-6(8)3-1-5(9)2-4-6/h5,9H,1-4H2

Upstream product

• 22515-18-0 4,4-difluorocyclohexanone 
• 23510-95-4 4-benzoyloxycyclohexanone 
• 556-48-9 1,4-Cyclohexanediol 
• 22419-33-6 (4.4-Difluor-cyclohexyl)-benzoat 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 176251-49-3 8,8-difluoro-1,4-dioxaspiro[4,5]decane 
• 937-14-4 3-chloro-benzenecarboperoxoic acid 
• 917383-03-0 4,4-difluoro-N-methoxy-N-methylcyclohexane-1-carboxamide 
• 122665-97-8 4,4-difluorocyclohexanecarboxylic acid 

Downstream Products

• 1154471-80-3 tert-butyl 8-[(4,4-difluorocyclohexyl)oxy]-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate 
• 1332633-14-3 2-(4,4-Difluoro-cyclohexyloxy)-4-fluoro-phenylamine 
• 1332633-13-2 2-(4,4-difluoro-cyclohexyloxy)-4-fluoro-1-nitro-benzene 
• 1355615-81-4 C₁₉H₂₅F₂N₅O₄ 
• 1067230-56-1 toluene-4-sulfonic acid 4,4-difluorocyclohexyl ester 
• 1445994-53-5 4-(2-(4,4-difluorocyclohexyloxy)-5-nitrophenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one 

Relevant articles and documents

BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF

Provided is a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. More particularly, provided are pharmaceutical composition of these compounds and methods of their preparation and use thereof.

ANTI-BACTERIAL COMPOUNDS

A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.

SUBSTITUTED 2,4,5,6-TETRAHYDROPYRROLO[3,4-C] PYRAZOLE AND 4,5,6,7-TETRAHYDRO-2H-PYRAZOLO [4,3-C] PYRIDINE COMPOUNDS AS GLYT1 INHIBITORS

The invention provides a chemical entity of Formula (I), wherein R1, R2, R3, R4, R5 and X have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.