Technology Process of ((1R,2R,3R)-2-(benzyloxymethyl)-3-phenylcyclopropyl)diphenylmethanol
There total 4 articles about ((1R,2R,3R)-2-(benzyloxymethyl)-3-phenylcyclopropyl)diphenylmethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
((1S,2S,3R)-2-((benzyloxy)methyl)-3-iodocyclopropyl)benzene;
With
tert.-butyl lithium;
In
diethyl ether; pentane;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
benzophenone;
In
diethyl ether; pentane;
at -78 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/chem.200902228
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diethylzinc / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
1.2: 15 h / -78 - -40 °C / Inert atmosphere; Darkness
2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2.2: 20 h / 0 - 20 °C / Inert atmosphere; Darkness
3.1: tert.-butyl lithium / pentane; diethyl ether / 0.33 h / -78 °C / Inert atmosphere
3.2: 16 h / -78 - 20 °C / Inert atmosphere
With
tert.-butyl lithium; diethylzinc; sodium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; pentane;
1.1: |Simmons-Smith Cyclopropanation / 1.2: |Simmons-Smith Cyclopropanation;
DOI:10.1002/chem.201202528
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 20 h / 0 - 20 °C / Inert atmosphere; Darkness
2.1: tert.-butyl lithium / pentane; diethyl ether / 0.33 h / -78 °C / Inert atmosphere
2.2: 16 h / -78 - 20 °C / Inert atmosphere
With
tert.-butyl lithium; sodium hydride;
In
tetrahydrofuran; diethyl ether; pentane;
DOI:10.1002/chem.201202528
