(S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide
• CAS No.: 260997-42-0
• Molecular Formula: C₂₁H₁₈F₃NO₂S
• Molecular Weight: 405.441
• Mol file: 260997-42-0.mol

Synonyms:(S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide

Chemical Property of (S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide

There total 29 articles about (S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) + 4-trifluoromethylphenylboronic acid (128796-39-4) → (S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide (260997-42-0)

Guidance literature:

With potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; C₂₈H₂₆O₅S; In water; toluene; at 50 ℃; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c9ra04836g

Reference yield: 96.0%

triphenylboroxine (3262-89-3) + 4-methyl-N-(4-trifluoromethylbenzylidene)-benzenesulfonamide (198012-02-1) → (S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide (260997-42-0)

Guidance literature:

With chlorobis(ethylene)rhodium(I) dimer; (S)-(-)-[η⁵-1-bis(3,5-di(tert-butyl-4-methoxyphenyl)phosphino-2-(3-diphenylphosphino-2-methylpropenyl)cylopentadienyl-P)] manganese(I) dicarbonyl; potassium hydroxide; In 1,4-dioxane; water; at 40 ℃; for 7h; Reagent/catalyst; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jacs.6b11243

Reference yield: 91.0%

4-methyl-N-(4-trifluoromethylbenzylidene)-benzenesulfonamide (198012-02-1) + phenylboronic acid (98-80-6) → (S)-(+)-N-[(4-trifluoromethylphenyl)phenylmethyl]-4-methylbenzenesulfonamide (260997-42-0)

Guidance literature:

With bis(ethylene)rhodium acetylacetonate; (R,R)-3,3'-[methyliminobis(methylene)]bis(1,1'-binaphtylene-2,2'-diol); In 1,2-dimethoxyethane; at 50 ℃; for 16h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200800631

upstream raw materials:

triphenylboroxine

(E)-4-methyl-N-(4-(trifluoromethyl)benzylidene)benzenesulfonamide

phenyltriisopropoxytitanium(IV)

p-toluenesulfonyl chloride