Technology Process of 4-(o-chlorophenyl)-4-dimethylaminocyclohexanone, ethylene ketal
There total 6 articles about 4-(o-chlorophenyl)-4-dimethylaminocyclohexanone, ethylene ketal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / TsOH / benzene / 6 h / Heating
2: 77 percent / NaOH / ethane-1,2-diol / 18 h / Heating
3: 84 percent / Et3N, (C6H5O)2PON3 / various solvent(s) / 2 h / 90 °C
4: 96 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
5: 2.) NaBH4 / 1.) H2O, MeOH, reflux, 4 h, 2.) H2O, MeOH, RT, 2 h
With
sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; ethylene glycol; benzene;
DOI:10.1021/jm00178a014
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / aq. H2SO4 / acetic acid / 24 h / Heating
2: 89 percent / TsOH / benzene / 6 h / Heating
3: 77 percent / NaOH / ethane-1,2-diol / 18 h / Heating
4: 84 percent / Et3N, (C6H5O)2PON3 / various solvent(s) / 2 h / 90 °C
5: 96 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
6: 2.) NaBH4 / 1.) H2O, MeOH, reflux, 4 h, 2.) H2O, MeOH, RT, 2 h
With
sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sulfuric acid; diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; ethylene glycol; acetic acid; benzene;
DOI:10.1021/jm00178a014
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 77 percent / NaOH / ethane-1,2-diol / 18 h / Heating
2: 84 percent / Et3N, (C6H5O)2PON3 / various solvent(s) / 2 h / 90 °C
3: 96 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
4: 2.) NaBH4 / 1.) H2O, MeOH, reflux, 4 h, 2.) H2O, MeOH, RT, 2 h
With
sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; diphenyl phosphoryl azide; triethylamine;
In
tetrahydrofuran; ethylene glycol;
DOI:10.1021/jm00178a014
