3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

Base Information

Chemical Name:3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester
CAS No.:632627-90-8
Molecular Formula:C₂₆H₂₃ClN₂O₃
Molecular Weight:446.933
Hs Code.:

Synonyms:3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

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Chemical Property of 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

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Technology Process of 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

There total 4 articles about 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 632625-42-4
1-[5-chloro-2-(benzyloxy)phenyl]-pentane-1,4-dione

: 1949-55-9
methyl 3,5-diaminobenzoate

: 632627-90-8
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

Guidance literature:: toluene-4-sulfonic acid; In toluene; for 2.5h; Heating / reflux;

Reference yield:

: 38544-16-0
2-(benzyloxy)-5-chlorobenzaldehyde

: 632627-90-8
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

2: toluene-4-sulfonic acid / toluene / 2.5 h / Heating / reflux

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; toluene-4-sulfonic acid; In ethanol; toluene;

Reference yield:

: 100-39-0
benzyl bromide

: 632627-90-8
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 60 °C

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

3: toluene-4-sulfonic acid / toluene / 2.5 h / Heating / reflux

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In DMF (N,N-dimethyl-formamide); ethanol; toluene;