Technology Process of (R)-3-(2-(benzyloxy)-1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)ethoxy)-2,6-difluorobenzonitrile
There total 8 articles about (R)-3-(2-(benzyloxy)-1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)ethoxy)-2,6-difluorobenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetraphosphorus decasulfide;
In
toluene;
for 1h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trifluoroacetic acid / 0.75 h / 20 °C
1.2: 20 h / 5 - 20 °C / pH 4
2.1: sulfuric acid / 16 h / Reflux
3.1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48.66 h / 0 - 20 °C
4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C
4.2: pH 4
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice
6.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
7.1: oxalyl dichloride / N,N-dimethyl-formamide / acetonitrile / 0.5 h / 20 °C / Cooling with ice
8.1: tetraphosphorus decasulfide / toluene / 1 h / Reflux
With
tetraphosphorus decasulfide; oxalyl dichloride; sulfuric acid; water; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; diethylazodicarboxylate;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 16 h / Reflux
2.1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48.66 h / 0 - 20 °C
3.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C
3.2: pH 4
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice
5.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
6.1: oxalyl dichloride / N,N-dimethyl-formamide / acetonitrile / 0.5 h / 20 °C / Cooling with ice
7.1: tetraphosphorus decasulfide / toluene / 1 h / Reflux
With
tetraphosphorus decasulfide; oxalyl dichloride; sulfuric acid; water; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;