(S)-3-BENZYLOXY-2-HYDROXY-PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: (S)-3-BENZYLOXY-2-HYDROXY-PROPIONIC ACID METHYL ESTER
• CAS No.: 127744-28-9
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918999090
• Mol file: 127744-28-9.mol

Synonyms:(S)-methyl 3-(benzyloxy)-2-hydroxypropanoate;REF DUPL: (S)-3-Benzyloxy-2-hydroxy-propionic acid methyl ester;Propanoic acid, 2-hydroxy-3-(phenylmethoxy)-, methyl ester, (2S)-

Chemical Property of (S)-3-BENZYLOXY-2-HYDROXY-PROPIONIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 2.93E-05mmHg at 25°C
• Boiling Point: 342.2°C at 760 mmHg
• PKA: 12.23±0.20(Predicted)
• Flash Point: 131.1°C
• PSA: 55.76000
• Density: 1.171g/cm³
• LogP: 0.73710
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-Benzyloxy-2-hydroxypropionicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-BENZYLOXY-2-HYDROXY-PROPIONIC ACID METHYL ESTER

There total 8 articles about (S)-3-BENZYLOXY-2-HYDROXY-PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-3-(benzyloxy)-2-hydroxypropanoic acid (130111-08-9,127744-27-8) + trimethyl orthoformate (149-73-5) → (S)-methyl 3-(benzyloxy)-2-hydroxypropanoate (127744-28-9)

Guidance literature:

(S)-3-(benzyloxy)-2-hydroxypropanoic acid; With thionyl chloride; In methanol; at 0 - 20 ℃; for 1h;

trimethyl orthoformate; at 20 ℃; for 21h;

DOI:10.1002/anie.202002328

Reference yield: 77.0%

methanol (67-56-1) + (S)-3-(benzyloxy)-2-hydroxypropanoic acid (130111-08-9,127744-27-8) → (S)-methyl 3-(benzyloxy)-2-hydroxypropanoate (127744-28-9)

Guidance literature:

methanol; (S)-3-(benzyloxy)-2-hydroxypropanoic acid; With acetyl chloride; at 0 - 20 ℃; for 0.75h;

With trimethyl orthoformate; at 20 ℃;

Reference yield: 68.0%

methanol (67-56-1) + (S)-3-(benzyloxy)-2-hydroxypropanoic acid (130111-08-9,127744-27-8) + trimethyl orthoformate (149-73-5) → (S)-methyl 3-(benzyloxy)-2-hydroxypropanoate (127744-28-9)

Guidance literature:

With sulfuric acid; for 16h; Reflux;

upstream raw materials:

methanol

(S)-3-(benzyloxy)-2-hydroxypropanoic acid

O-Benzyl-L-serine

trimethyl orthoformate

Downstream raw materials:

(R)-3-benzyloxy-1,2-propanediol

(R)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzene sulfonate

(2S)-3-(benzyloxy)propane-1,2-diol

(S)-benzyl glycidyl ether

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