(R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Base Information

Chemical Name:(R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide
CAS No.:1403883-46-4
Molecular Formula:C₁₅H₁₀ClF₂N₃O₃S
Molecular Weight:385.779
Hs Code.:

Synonyms:(R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

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Chemical Property of (R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

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Technology Process of (R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

There total 6 articles about (R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1403884-25-2
(R)-3-(2-(benzyloxy)-1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)ethoxy)-2,6-difluorobenzonitrile

: 1403883-46-4
(R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Guidance literature:: (R)-3-(2-(benzyloxy)-1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)ethoxy)-2,6-difluorobenzonitrile; With sulfuric acid; at 60 ℃; for 0.5h;

With sodium hydroxide; In water; Cooling with ice;

Reference yield:

: 1403884-21-8
(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoic acid

: 1403883-46-4
(R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

3.1: oxalyl dichloride / N,N-dimethyl-formamide / acetonitrile / 0.5 h / 20 °C / Cooling with ice

4.1: tetraphosphorus decasulfide / toluene / 1 h / Reflux

5.1: sulfuric acid / 0.5 h / 60 °C

5.2: Cooling with ice

With tetraphosphorus decasulfide; oxalyl dichloride; sulfuric acid; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 1403884-02-5
(R)-3-benzyloxy-2-(3-carbamoyl-2,4-difluoro-phenoxy)propionic acid methyl ester

: 1403883-46-4
(R)-3-(1-(6-chlorothiazolo[5,4-b]pyridin-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

1.2: pH 4

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

4.1: oxalyl dichloride / N,N-dimethyl-formamide / acetonitrile / 0.5 h / 20 °C / Cooling with ice

5.1: tetraphosphorus decasulfide / toluene / 1 h / Reflux

6.1: sulfuric acid / 0.5 h / 60 °C

6.2: Cooling with ice

With tetraphosphorus decasulfide; oxalyl dichloride; sulfuric acid; water; triethylamine; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;