((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline

Base Information

Chemical Name:((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline
CAS No.:1596346-48-3
Molecular Formula:C₂₆H₄₀N₄O₈S
Molecular Weight:568.692
Hs Code.:

Synonyms:((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline

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Chemical Property of ((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline

Chemical Property:

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Technology Process of ((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline

There total 7 articles about ((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1596346-48-3
((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol

3: triethylamine / dichloromethane / 12 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

5: palladium 10% on activated carbon; hydrogen / methanol

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12.16 h / 0 - 20 °C

7: lithium hydroxide monohydrate; water / methanol / 4 h

With sodium azide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ra47039c

Reference yield:

: methyl (S)-1-((2-aminophenyl)sulfonyl)pyrrolidine-2-carboxylate

: 1596346-48-3
((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

3: palladium 10% on activated carbon; hydrogen / methanol

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12.16 h / 0 - 20 °C

5: lithium hydroxide monohydrate; water / methanol / 4 h

With sodium azide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ra47039c

Reference yield:

: 1568827-22-4
(S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

: 1596346-48-3
((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

2: palladium 10% on activated carbon; hydrogen / methanol

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12.16 h / 0 - 20 °C

4: lithium hydroxide monohydrate; water / methanol / 4 h

With sodium azide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ra47039c