tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate
CAS No.:1596346-41-6
Molecular Formula:C₃₇H₆₁N₇O₉S
Molecular Weight:779.999
Hs Code.:

tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

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Suppliers and Price of tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

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Chemical Property of tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

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Technology Process of tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

There total 9 articles about tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1596346-40-5
methyl 2-(2-((2S)-1-((2-(2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-methylpropanamido)phenyl)sulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-2-methylpropanoate

: 74-89-5
methylamine

: 1596346-41-6
tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

Guidance literature:: In methanol; for 8h;
DOI:10.1039/c3ra47039c

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1596346-41-6
tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol

3: triethylamine / dichloromethane / 12 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

5: palladium 10% on activated carbon; hydrogen / methanol

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12.16 h / 0 - 20 °C

7: lithium hydroxide monohydrate; water / methanol / 4 h

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

9: methanol / 8 h

With sodium azide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ra47039c

Reference yield:

: methyl (S)-1-((2-aminophenyl)sulfonyl)pyrrolidine-2-carboxylate

: 1596346-41-6
tert-butyl (4-methyl-1-((2-methyl-1-((2-(((2S)-2-((4-methyl-1-((2-methyl-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)sulfonyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

3: palladium 10% on activated carbon; hydrogen / methanol

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12.16 h / 0 - 20 °C

5: lithium hydroxide monohydrate; water / methanol / 4 h

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

7: methanol / 8 h

With sodium azide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ra47039c