tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate

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Chemical Name:tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate
CAS No.:1355254-60-2
Molecular Formula:C₂₉H₃₀F₃N₃O₄
Molecular Weight:541.57
Hs Code.:

Synonyms:tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate

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Chemical Property of tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate

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Technology Process of tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate

There total 5 articles about tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1140462-04-9
2’-methyl-2-(trifluoromethyl)biphenyl-4-carboxylic acid

: 1149727-74-1
tert-butyl [(1R)-1-{4-[(hydroxyamino)(imino)methyl]phenyl}ethyl]carbamate

: 1355254-60-2
tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate

Guidance literature:: 2’-methyl-2-(trifluoromethyl)biphenyl-4-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 5 - 9 ℃; for 1h; Inert atmosphere; Cooling with ice;

tert-butyl [(1R)-1-{4-[(hydroxyamino)(imino)methyl]phenyl}ethyl]carbamate; In tetrahydrofuran; for 2.5h;

Reference yield: 87.0%

: 1140462-04-9
2’-methyl-2-(trifluoromethyl)biphenyl-4-carboxylic acid

: tert-butyl {3-[(Z)-amino(hydroxyimino)methyl]benzyl}methylcarbamate

: 1355254-60-2
tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate

Guidance literature:: 2’-methyl-2-(trifluoromethyl)biphenyl-4-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; for 1h; Inert atmosphere; Cooling with ice;

tert-butyl {3-[(Z)-amino(hydroxyimino)methyl]benzyl}methylcarbamate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 107317-58-8
4-bromo-3-trifluoromethylbenzoic acid methyl ester

: 1355254-60-2
tert-butyl [(1R)-1-(4-{(Z)-amino[({[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 3.08 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / ethanol / 2 h / 20 - 60 °C

2.2: pH 2

3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / 5 - 9 °C / Inert atmosphere; Cooling with ice

3.2: 2.5 h

With 4-methyl-morpholine; potassium carbonate; sodium hydroxide; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; toluene;