trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

Base Information

Chemical Name:trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile
CAS No.:1418199-76-4
Molecular Formula:C₁₇H₁₈IN₅O
Molecular Weight:435.267
Hs Code.:

Synonyms:trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

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Chemical Property of trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

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Technology Process of trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

There total 1 articles about trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1315490-71-1
trans-4-(2-((R)-1-hydroxyethyl)imidazo[4,5-d]pyrrolo[2,3-b]-pyridin-1(6H)-yl)cyclohexanecarbonitrile

: 1418199-76-4
trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

Guidance literature:: With N-iodo-succinimide; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 44.0%

: 1418199-76-4
trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

: 98-09-9
benzenesulfonyl chloride

: 1418199-77-5
trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1418199-76-4
trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

: 1418199-78-6
trans-6-benzenesulfonyl-1-(4-cyano-cyclohexyl)-2-((R)-1-hydroxyethyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacene-8-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane; tetrahydrofuran / 18 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 42 h / 100 °C / Inert atmosphere

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;