trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

Base Information

Chemical Name:trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile
CAS No.:1418199-77-5
Molecular Formula:C₂₃H₂₂IN₅O₃S
Molecular Weight:575.43
Hs Code.:

Synonyms:trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

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Chemical Property of trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

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Technology Process of trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

There total 2 articles about trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1418199-76-4
trans-4-[2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

: 98-09-9
benzenesulfonyl chloride

: 1418199-77-5
trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1315490-71-1
trans-4-(2-((R)-1-hydroxyethyl)imidazo[4,5-d]pyrrolo[2,3-b]-pyridin-1(6H)-yl)cyclohexanecarbonitrile

: 1418199-77-5
trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / tetrahydrofuran / 18 h / 20 °C

2: dmap; triethylamine / dichloromethane; tetrahydrofuran / 18 h / 20 °C

With dmap; N-iodo-succinimide; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield: 55.0%

: 685822-32-6,763040-87-5,131069-87-9
copper(I) cyanide

: 1418199-77-5
trans-4-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-8-iodo-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclohexanecarbonitrile

: 1418199-78-6
trans-6-benzenesulfonyl-1-(4-cyano-cyclohexyl)-2-((R)-1-hydroxyethyl)-1,6-dihydro-1,3,5,6-tetraaza-as-indacene-8-carbonitrile

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 42h; Inert atmosphere;