2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester
CAS No.:136304-72-8
Molecular Formula:C₂₅H₂₀ClN₃O₂
Molecular Weight:429.906
Hs Code.:

Synonyms:2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester

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Chemical Property of 2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester

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Technology Process of 2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester

There total 9 articles about 2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 79-04-9
chloroacetyl chloride

: 136285-69-3
ethyl 3-amino-2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>benzoate

: 136304-72-8
2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester

Guidance literature:: In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00067a016

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 136304-72-8
2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

7: 78 percent / ethanol / 1.5 h / Heating

8: 76 percent / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; thionyl chloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016

Reference yield:

: 73833-13-3
acid chloride of 1-methylhydrogen-3-nitrophthalate

: 136304-72-8
2-Chloromethyl-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-benzoimidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaN₃ / acetone; H₂O / 1 h

2: 1.5 h / Heating

3: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

5: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

6: 78 percent / ethanol / 1.5 h / Heating

7: 76 percent / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; In ethanol; dichloromethane; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm00067a016